Sermorelin 10mg

Sermorelin is a synthetic 29-amino acid peptide corresponding to the first 29 amino acids of the 44-amino acid human growth hormone-releasing hormone (GHRH). It has a molecular weight of 3357.9 g/mol and CAS number 86168-78-7. Sermorelin retains full biological activity as the minimal fragment required for GHRH receptor binding and activation.

Research shows sermorelin stimulates the anterior pituitary to synthesize and secrete growth hormone through binding to GHRH receptors on somatotroph cells. Studies demonstrate it preserves the natural pulsatile pattern of GH release and maintains negative feedback through somatostatin and IGF-1 pathways. This physiological regulation distinguishes its mechanism from direct GH administration.

Preclinical and clinical studies document sermorelin’s effects on body composition, with research showing increases in lean body mass, reductions in adipose tissue, and improvements in sleep architecture, particularly deep wave sleep stages associated with peak GH secretion. Research in aging models demonstrates restoration of youthful GH secretion patterns.

Additional research has explored sermorelin’s effects on bone mineral density, immune function markers, and cardiovascular parameters. Studies in growth hormone deficiency models show normalization of IGF-1 levels without supraphysiological GH exposure.

Each vial contains 10mg of lyophilized sermorelin at greater than 99% purity, independently verified by HPLC and mass spectrometry.