Semax 10mg

Semax is a synthetic heptapeptide derived from the N-terminal fragment of adrenocorticotropic hormone (ACTH 4-10) with the sequence Met-Glu-His-Phe-Pro-Gly-Pro. It has a molecular weight of 813.9 g/mol and CAS number 80714-61-0. The Pro-Gly-Pro C-terminal extension enhances enzymatic stability, extending its biological half-life compared to native ACTH fragments.

Research has characterized Semax as a nootropic and neuroprotective peptide with documented effects on cognitive function, neurotransmitter systems, and neuroplasticity. Studies demonstrate it upregulates brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) expression in the hippocampus and cortex, promoting neuronal survival and synaptic plasticity.

Preclinical neuroprotection research shows Semax reduces infarct volume in cerebral ischemia models, decreases oxidative stress markers, and modulates inflammatory gene expression in neural tissue. Studies document enhanced recovery of motor and cognitive function following experimentally induced brain injury. The peptide’s mechanism involves modulation of the melanocortin system through MC3R and MC4R receptor interactions.

Additional research areas include Semax’s effects on attention and memory consolidation, with studies showing enhanced performance in spatial learning and passive avoidance paradigms. Gene expression profiling reveals modulation of immune response genes, neurotransmitter receptor expression, and vascular endothelial growth factor pathways in brain tissue.

Each vial contains 10mg of lyophilized Semax at greater than 99% purity, verified by HPLC and mass spectrometry analysis.